Neighborhood disorder and ovarian cancer survival in Black women
Ovarian cancer (OC) is the fifth leading cause of cancer mortality among women in the US. Black women experience significantly lower OC survival than White women. Evidence suggests that this disparity is not solely the result of barriers to healthcare access but may also be impacted by other factors, including neighborhood social characteristics. To investigate this further, this study developed an approach for remotely estimating the degree of physical disorder (PD) in neighborhoods using structured audits of Google Street View imagery for participants in the AACES, a multi-site population-based study of Black women newly diagnosed with OC. We then assessed whether neighborhood disadvantage (ND) and PD were associated with overall survival. We fit Weibull accelerated failure time models to assess the association of both PD and ND with survival among 471 Black women with OC (n = 317 deaths). Both PD (event time ratio (ETR), 0.99; 95% CI, 0.98, 1.00) and Area Deprivation Index (ETR: 0.96, 95% CI: 0.94, 1.00) were associated with shorter survival. The results suggest that both physical and social neighborhood characteristics may impact survival in woman with OC, but further research is warranted.
Authors
- Elisa V. Bandera (ORCID: https://orcid.org/0000-0002-8789-2755)
- Michele L. Coté (ORCID: https://orcid.org/0000-0003-0312-1601)
- Edward Peters (ORCID: https://orcid.org/0000-0003-4928-6532)
- Melissa L. Bondy (ORCID: https://orcid.org/0000-0002-0278-414X)
- Lindsay Jane Collin (ORCID: https://orcid.org/0000-0003-0170-2592)
- Stephen John Mooney (ORCID: https://orcid.org/0000-0001-9092-938X)
- Anthony J. Alberg (ORCID: https://orcid.org/0000-0002-3777-0266)
- Hannah Mandle (ORCID: https://orcid.org/0000-0002-0277-9607)
- Kendra L. Ratnapradipa (ORCID: https://orcid.org/0000-0003-0265-2400)
- Courtney E. Johnson (ORCID: https://orcid.org/0000-0003-4980-3499)
- Paul Terry (ORCID: https://orcid.org/0000-0002-0353-9197)
- Lauren Cole Peres (ORCID: https://orcid.org/0000-0002-6620-8600)
- Christopher R. Pierson (ORCID: https://orcid.org/0000-0002-5553-3096)
- Theresa A. Hastert (ORCID: https://orcid.org/0000-0001-6251-6422)
- Namita Khanna (ORCID: https://orcid.org/0000-0001-9064-451X)
- Joellen M. Schildkraut (ORCID: https://orcid.org/0000-0002-0990-9339)
- Anke Huels
- Andrew Lawson
Institutions
- Rutgers, The State University of New Jersey (US)
- Indiana University Health (US)
- Emory University (US)
- Medical University of South Carolina (US)
- University of South Carolina (US)
- University of Tennessee Health Science Center (US)
- Wayne State University (US)
- University of Washington (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Knoxville College (US)
- Moffitt Cancer Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Indiana Cancer Consortium (US)
- Richard M. Fairbanks Foundation (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Nebraska Medical Center (US)
- University of Tennessee at Knoxville (US)
- Stanford University (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- American Journal of Epidemiology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1093/aje/kwaf159
- Citations
- 1
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.05