Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumors

Tumors in mcPXA share molecular characteristics with histologically defined PXA, and high-grade histologic features can help predict their clinical behavior. The use of an epigenetic classification of PXA reveals that this group of tumors is more common than previously appreciated and warrants in-depth study to identify efficacious therapeutic options.

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Publication Details

Journal
Neuro-Oncology Advances
Published
2025-01-01
DOI
https://doi.org/10.1093/noajnl/vdaf089
Citations
2
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
3.25
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article

Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumors

Ina Lee, Sanda Alexandrescu, Mark Gilbert, Matthew McCord et al.
2 citations
Neuro-Oncology Advances
Glioma Diagnosis and Treatment
3.25
article

Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumors

Ina Lee, Sanda Alexandrescu, Mark Gilbert, Matthew McCord, Nitin R. Wadhwani, Sahara Cathcart, Jeffrey Nirschl, Han Sung Lee, Jennifer Cotter, Kristyn Galbraith, Ahmed Gilani, Marco Prinz, Christian Thomas, Diana Thomas, Lorraina Robinson, Mark Raffeld, Sima Ferman, Christina K. Ferrone, Daniel Schrimpf, Felipe D’Almeida Costa, Osório Lopes Abath Neto, Rachael A. Vaubel, Patrick J. Cimino, Qinwen Mao, Jason V. Gregory, Jaiyeola Thomas-Ogunniyi, Azadeh Ebrahimi, Rust Turakulov, Stewart G. Neill, Peter Pytel, Jens Schittenhelm, Christopher H. Dampier, Sharika Rajan, Zied Abdullaev, Angus Toland, Niharika Shah, Terri Armstrong, Andreas von Deimling, Courtney Ketchum, Felipe Andreiuolo, Nima Etminam, Kyle Conway, Byram H. Ozer, Kenneth Aldape, Karen Dazelle, Caterina Giannini, Michael S. Marshall, Matija Snuderl, Miriam Ratliff, Tiffany G. Baker, Jing Wu, Omkar Singh, Sebastian Brandner, Maria Beatriz Lopes, Hye‐Jung Chung, Martha Quezado, Guido Reifenberger, Marta Penas‐Prado, Werner Paulus
article en
2 citations

Abstract

Tumors in mcPXA share molecular characteristics with histologically defined PXA, and high-grade histologic features can help predict their clinical behavior. The use of an epigenetic classification of PXA reveals that this group of tumors is more common than previously appreciated and warrants in-depth study to identify efficacious therapeutic options.

Neuro-Oncology AdvancesVol. 7(1)
Northwestern University (US), University of Iowa (US), Rush University Medical Center (US), Boston Children's Hospital (US), Lurie Children's Hospital (US), Nebraska Medical Center (US), Nationwide Children's Hospital (US), Mayo Clinic (US), Children's Hospital of Los Angeles (US), University College London Hospitals NHS Foundation Trust (GB), Emory University (US), Medical University of South Carolina (US), University of Freiburg (DE), German Cancer Research Center (DE), University of Utah (US), Heidelberg University (DE), University of Michigan (US), University of Virginia Health System (US), Walter Reed National Military Medical Center (US), University Hospital Heidelberg (DE), AC Camargo Hospital (BR), University of Illinois Chicago (US), Universidade do Estado do Rio de Janeiro (BR), NYU Langone Health (US), Düsseldorf University Hospital (DE), Laboratório Bacchi (BR), Children's Hospital Colorado (US), Northwestern University (PH), VA Ann Arbor Healthcare System (US), D’Or Institute for Research and Education (BR), University Hospital Münster (DE), National Institute of Neurological Disorders and Stroke (US), Michigan Medicine (US), Mayo Clinic in Arizona (US), Lurie Children's Hospital (US), National Cancer Institute (US), Hertie Institute for Clinical Brain Research (DE), Instituto Nacional de Câncer - INCA (BR), Mayo Clinic in Florida (US), Northwestern Medicine (US), Center for Cancer Research (US), Boston Children's Museum (US), National Hospital for Neurology and Neurosurgery (GB), University Medical Centre Mannheim (DE), The University of Texas Health Science Center (US), Instituto Estadual do Cérebro Paulo Niemeyer (BR), Heinrich Heine University Düsseldorf (DE), University College London (GB), University of Nebraska Medical Center (US), University of Tübingen (DE), University of California, Davis (US), University of Colorado Denver (US), University of Bologna (IT), Stanford University (US)
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Openalex Percentile: Top 8%
Glioma Diagnosis and Treatment
3.25
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