Targeting immune checkpoints as a new therapeutic strategy for intra-hepatic cholangiocarcinoma
Our data indicated that AUNP-12 effectively harbors IH-CCA progression and improves the survival rate of mice. AUNP-12 acts as an immune check point blocker that specifically inhibits PD-1/PD-L1 binding, activates cytotoxic T-lymphocytes, and downregulates TGF-β signaling pathway.
Authors
- Othman F. Abdelzaher (ORCID: https://orcid.org/0000-0003-0101-2962)
- Ahmed B. M. Mehany
- Ola A. El-Feky (ORCID: https://orcid.org/0000-0002-2662-4765)
- Eman G. Khedr (ORCID: https://orcid.org/0000-0003-2968-7494)
- Martha Seif
Institutions
- Al-Azhar University (EG)
- Tanta University (EG)
Publication Details
- Journal
- Bioimpacts
- Published
- 2025-07-13
- DOI
- https://doi.org/10.34172/bi.31086
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00