Halting Hypercaloric Feeding in Liver Chimeric Mice Rapidly Resolves Human Hepatocyte Steatosis
PNPLA3 3 148-isoleucine variant human hepatocytes in chimeric mice rapidly resolve steatosis with a gradual improvement in steatohepatitis activity, which is delayed in PNPLA3-148M hepatocytes. This supports a model in which altered lipid mobilization in PNPLA3-148M hepatocytes contributes to more active steatohepatitis.
Authors
- Corrine Quirk
- Luiz C. A. Barbosa (ORCID: https://orcid.org/0000-0002-5395-9608)
- Alireza Ramandi (ORCID: https://orcid.org/0000-0001-8247-4258)
- Baran A. Ersoy (ORCID: https://orcid.org/0000-0003-4848-5097)
- Clifton G. Fulmer (ORCID: https://orcid.org/0000-0003-1453-9421)
- Ype P. de Jong (ORCID: https://orcid.org/0000-0001-6357-2370)
- Yichen Zhou
- Luis Chiriboga (ORCID: https://orcid.org/0000-0002-2028-6873)
- Eleftherios Michailidis (ORCID: https://orcid.org/0000-0002-9907-4346)
- Vijay Soni (ORCID: https://orcid.org/0000-0002-3395-7429)
- James M. Jordan (ORCID: https://orcid.org/0000-0002-7620-462X)
- Aditya Upadhyay (ORCID: https://orcid.org/0000-0003-2572-3822)
- Mohammad Kabbani (ORCID: https://orcid.org/0000-0001-9556-384X)
- Maha Maaliki
- Chenhui Zou
- Björn Hartleben
- Georgios Dangas
Institutions
- Florida State University (US)
- Cleveland Clinic (US)
- Emory University (US)
- Cornell University (US)
- Medizinische Hochschule Hannover (DE)
- Weill Cornell Medicine (US)
- New York University (US)
- Rockefeller University (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100758
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35