New Tirucallane-Type Triterpenes Isolated from <i>Commiphora oddurensis</i> from Ethiopia with Anticancer Activity
Three new tirucallane-type triterpenes, tirucalla-7,24-diene-1β,3β-diol (oddurensinoid <b>B</b>), tirucalla-7-ene-1β,3β,25-triol (oddurensinoid <b>H</b>), and tirucalla-7, 24-diene-3β-ol-1-<i>O</i>-β-d-glucopyranoside (oddurensinoid <b>K</b>), were isolated from the resin of <i>Commiphora oddurensis</i> harvested from Ethiopia, Africa. Their structures were elucidated by one-dimensional (1D) NMR, two-dimensional (2D) NMR, and high-resolution mass spectrometry (HRMS). All three compounds were tested for their anticancer activity against HeLa cell lines. They all exhibit anticancer activity, with oddurensinoid <b>H</b> the most potent with IC<sub>50</sub> of 0.017 mg/mL (36.9 μM).
Authors
- Paulos Yohannes (ORCID: https://orcid.org/0000-0001-7570-9960)
- Qiyue Mao (ORCID: https://orcid.org/0000-0002-2834-5890)
- Binghe Wang (ORCID: https://orcid.org/0000-0002-2200-5270)
- Aman Dekebo (ORCID: https://orcid.org/0000-0003-4767-606X)
- Xiaoxiao Yang (ORCID: https://orcid.org/0000-0001-9895-9559)
- Siming Wang (ORCID: https://orcid.org/0000-0001-9299-8477)
- Lu Wen (ORCID: https://orcid.org/0000-0003-2203-5119)
- Zhenming Du (ORCID: https://orcid.org/0000-0001-9736-3198)
- Ermias Dagne
- Taame G. Seyoum
Institutions
- Georgia State University (US)
- Addis Ababa University (ET)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1021/acsomega.5c03203
- Primary Topic
- Pharmacological Effects of Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Georgia Research Alliance