Nuclear spin hyperpolarization of pyruvate enables longitudinal monitoring of treatment response in intestinal tumor organoids
Hyperpolarized [1-13C]pyruvate combined with NMR enables noninvasive, longitudinal monitoring of tumor metabolism in intestinal organoids while preserving cell viability and recultivation potential, bridging preclinical and clinical applications and affirming the method's potential for targeted metabolic imaging as a novel diagnostic and treatment control approach in cancer medicine.
Authors
- Andrey N. Pravdivtsev (ORCID: https://orcid.org/0000-0002-8763-617X)
- Josh P. Peters (ORCID: https://orcid.org/0000-0003-1019-4067)
- Jan‐Bernd Hövener (ORCID: https://orcid.org/0000-0001-7255-7252)
- Philip Rosenstiel (ORCID: https://orcid.org/0000-0002-9692-8828)
- Stefan Schreiber (ORCID: https://orcid.org/0000-0003-2254-7771)
- Konrad Aden (ORCID: https://orcid.org/0000-0003-3482-7316)
- Charbel D. Assaf (ORCID: https://orcid.org/0000-0003-1968-2112)
- Farhad Haj Mohamad (ORCID: https://orcid.org/0009-0005-2238-5639)
- Xiang Hang
Institutions
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1002/mrm.70008
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Else Kröner-Fresenius-Stiftung
- European Regional Development Fund