Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study
The results of the study provided possible causal evidence for the involvement of circulating inflammatory proteins in the pathogenesis of eleven hematologic malignancies. Nine proteins with cross-cancer effects were of special interest, and their potential as targets in the therapeutic intervention of blood malignancies was highlighted.
Authors
- Yongguo Yu (ORCID: https://orcid.org/0000-0002-4472-0910)
- Han Liu (ORCID: https://orcid.org/0000-0002-0022-1861)
- Chaoqun Lu
- Zixuan Huang
- Yuling Zheng (ORCID: https://orcid.org/0009-0006-6700-3750)
- Huijian Zheng
- Minghui Wang (ORCID: https://orcid.org/0000-0001-9171-4962)
- Dan Li (ORCID: https://orcid.org/0000-0002-1609-1539)
- Wenjie Zhang (ORCID: https://orcid.org/0000-0002-6878-8127)
- Li Jiang (ORCID: https://orcid.org/0000-0003-2652-0699)
- Yixin Wang (ORCID: https://orcid.org/0000-0002-8118-4846)
- Shufeng Xie
- Chunjun Zhao
- Huajian Xian
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Hematology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1080/16078454.2025.2538327
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China