Increasing Paternal Age Associated With Elevated Risk of De Novo Mutations in Offspring Diagnosed With Sporadic Bilateral Retinoblastoma
Our study suggests a significant role for increasing paternal age in the development of sporadic bilateral retinoblastoma by elevating the risk of de novo RB1 mutations in offspring. These findings shed light on the potential causal mechanisms underlying the development of sporadic retinoblastoma.
Authors
- Tiffany M. Chambers (ORCID: https://orcid.org/0000-0001-7618-7009)
- Greta R. Bunin
- Maral Adel Fahmideh (ORCID: https://orcid.org/0000-0002-9930-8288)
- Philip J. Lupo (ORCID: https://orcid.org/0000-0003-0978-5863)
- Arupa Ganguly (ORCID: https://orcid.org/0000-0003-4527-3216)
Institutions
- Children's Hospital of Philadelphia (US)
- Baylor College of Medicine (US)
- Texas Oncology (US)
- Children's Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1002/pbc.31936
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health