Contribution of chloride channels to the action potential and contraction in human myometrium during labour
The ANO1/TMEM16A chloride conductance 'clamps' the human myometrial membrane potential at a depolarized plateau, extending calcium influx and prolonging contraction, including that evoked by oxytocin. This function of ANO1 and its enhanced expression in labour are likely critical for the large and prolonged contractions required for expeditious birth of the offspring.
Authors
- Harold A. Coleman (ORCID: https://orcid.org/0000-0002-5782-441X)
- Ranga E. Siriwardhana
- Penelope M. Sheehan (ORCID: https://orcid.org/0000-0003-2753-5243)
- Shaun P. Brennecke (ORCID: https://orcid.org/0000-0003-3070-6971)
- Helena C. Parkington (ORCID: https://orcid.org/0000-0002-0590-651X)
- Mary A. Tonta
- Marianne Tare (ORCID: https://orcid.org/0000-0003-4574-9368)
Institutions
- Royal Women's Hospital (AU)
- The University of Melbourne (AU)
- Discovery Institute (US)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1111/bph.70146
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00