Clinical Connections

Distinct peripheral blood biomarker signatures are associated with RA-ILD and implicate a wide range of biologic pathways in RA-ILD. Peripheral blood biomarker signatures improve ILD discrimination beyond clinical risk factors alone. Incorporation of peripheral blood biomarkers into predictive models could help overcome the limited predictive value of clinical risk factors for RA-ILD.SUMMARY STING-associated vasculopathy with onset in infancy (SAVI) is a rare and severe treatments like JAK inhibitors often provide only partial control of symptoms and can In this report, we describe a young adult with SAVI who showed limited clinical improvement with JAK inhibition and with dazukibart, a monoclonal antibody targeting and particularly when responses to JAK inhibitors are incomplete.