Endoplasmic Reticulum Stress Inhibits the Neuronal Differentiation of Human Stem Cells From Apical Papillae by Attenuating the Activity of <scp>ERK</scp>–<scp>IRE1α</scp> Axis In Vitro
Severe ER stress inhibits the neuronal differentiation of SCAPs via decreasing ERK1/2 and IRE1α activity, whereas ER stress at an appropriate level is essential for the neuronal differentiation of SCAPs.
Authors
- Junqing Liu (ORCID: https://orcid.org/0000-0001-5129-1678)
- Leyi Chen (ORCID: https://orcid.org/0000-0002-7090-3788)
- Chengfei Zhang (ORCID: https://orcid.org/0000-0002-6016-9436)
- Zhaodan Wang (ORCID: https://orcid.org/0000-0002-7602-4207)
- Shulan Lin
- Jingyi Ye (ORCID: https://orcid.org/0009-0002-7021-025X)
- Buling Wu (ORCID: https://orcid.org/0000-0001-5499-0693)
Institutions
- Nanfang Hospital (CN)
- Stomatology Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1111/iej.70003
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Glaucoma Research Foundation