Incidence and risk factors for musculoskeletal adverse effects associated with daptomycin in patients receiving outpatient parenteral antimicrobial therapy
The incidence of CPK elevation was similar previously reported rates. This expands the literature to patients with daptomycin doses>6 mg/kg and prolonged durations of therapy. The incidence of CPK elevation and time to onset of 9-16 days supports the current recommendations for weekly lab monitoring.
Authors
- Stephen Neely
- Joseph Sassine (ORCID: https://orcid.org/0000-0001-8730-8929)
- Emily A Siegrist (ORCID: https://orcid.org/0000-0002-4282-4134)
- Kiya K. Bennett
- Bryan P. White (ORCID: https://orcid.org/0000-0001-5657-7069)
- Mark Wiley
Institutions
- Oklahoma City University (US)
- OU Health
- University of Oklahoma Health Sciences Center (US)
- University of Oklahoma (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10087
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00