An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter
An admittance technology (AT) pulmonary artery catheter was developed to measure instantaneous right ventricular (RV) pressure-volume loops. Admittance RV volumes were validated in vivo through 10 swine subjected to positive and negative hemodynamic perturbations compared with magnetic resonance imaging and ex vivo RV foam casts. Finite element analysis demonstrated the AT electric field was confined to RV blood volume. RV pressure-volume loops demonstrated anticipated changes in all hemodynamics, and end-diastolic volumes were equal to magnetic resonance imaging and foam casts (P = NS). Increasing RV end-diastolic volumes in response to acute cardiac injury were also measured (P < 0.001). We report validating an AT pulmonary artery catheter in a swine model.
Authors
- Alexander J. Moody (ORCID: https://orcid.org/0000-0003-1834-2175)
- Joel Michalek (ORCID: https://orcid.org/0000-0003-3021-773X)
- Drew Nolen
- Aleksandra Gruslova (ORCID: https://orcid.org/0000-0003-3358-7015)
- Clay Heighten
- Vivek Jani (ORCID: https://orcid.org/0000-0002-3811-4973)
- Mohammed Aslam (ORCID: https://orcid.org/0000-0003-4560-8661)
- Luis A Diaz Sanmartin (ORCID: https://orcid.org/0009-0002-0465-2930)
- Fawaz Alenezi
- Marc D. Feldman
- James John Elliott
- J. W. Valvano
Institutions
- Johns Hopkins University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Johns Hopkins Medicine (US)
- Duke Medical Center (US)
- The University of Texas at San Antonio (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1016/j.jacbts.2025.101326
- Citations
- 1
- Primary Topic
- Hemodynamic Monitoring and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- University of Texas Health Science Center at San Antonio
- National Heart, Lung, and Blood Institute
- National Institute of Biomedical Imaging and Bioengineering