Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma

A more hypermethylated RE profile was linked to worse survival among Black women with HGSOC, highlighting the potential of RE methylation as a prognostic biomarker. Further research is needed to understand the underlying biological mechanisms and their implications in ovarian cancer biology and treatment.

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Publication Details

Journal
Clinical Epigenetics
Published
2025-07-30
DOI
https://doi.org/10.1186/s13148-025-01942-9
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.00
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article

Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma

Kristian Hallermalm, Brooke L. Fridley, Elisa V. Bandera, Michele L. Coté et al.
Clinical Epigenetics
Epigenetics and DNA Methylation
article

Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma

Kristian Hallermalm, Brooke L. Fridley, Elisa V. Bandera, Michele L. Coté, Edward Peters, Melissa L. Bondy, Christelle Colin, Anthony J. Alberg, Tania Mesa, Jeffrey R. Marks, Courtney E. Johnson, Sean Yoder, Chad D. Huff, Irma Vlasac, Jennifer A. Doherty, Katherine A. Lawson‐Michod, Paul Terry, Brock C. Christensen, Lauren Cole Peres, Lucas A. Salas, Jing‐Yi Chern, Theresa A. Hastert, Michelle A.T. Hildebrandt, Joellen M. Schildkraut, Andrew Berchuck, Andrew Lawson, Dana Roeber
article en

Abstract

A more hypermethylated RE profile was linked to worse survival among Black women with HGSOC, highlighting the potential of RE methylation as a prognostic biomarker. Further research is needed to understand the underlying biological mechanisms and their implications in ovarian cancer biology and treatment.

Clinical EpigeneticsVol. 17(1)
Rutgers, The State University of New Jersey (US), Dartmouth College (US), Indiana University Health (US), Children's Mercy Hospital (US), The University of Texas MD Anderson Cancer Center (US), Emory University (US), Medical University of South Carolina (US), University of South Carolina (US), Duke University (US), Wayne State University (US), University of Utah (US), Huntsman Cancer Institute (US), University of Tennessee Medical Center (US), Moffitt Cancer Center (US), The Barbara Ann Karmanos Cancer Institute (US), Indiana University – Purdue University Indianapolis (US), University of Nebraska Medical Center (US), University of Tennessee at Knoxville (US), Stanford University (US), University of Edinburgh (GB)
Openalex Percentile: Top 83%
Epigenetics and DNA Methylation
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