Optimal intervention design for tonsillitis transmission via compartmental modeling with stability analysis and control strategies

Tonsillitis represents a significant public health concern, particularly for children and adolescents, leading to substantial socioeconomic costs. To address this, we developed a compartmental mathematical model to investigate the disease's transmission dynamics and determine optimal intervention strategies. The model's analysis establishes the conditions for disease persistence and eradication. Using optimal control theory, we assessed the effectiveness of preventative measures as well as treatments for both acute and chronic stages of the infection. Our findings demonstrate that a multi-faceted approach is superior to any single strategy. The most effective and robust reduction in disease prevalence is achieved by an integrated strategy that combines prevention with enhanced treatment protocols. This study offers a quantitative tool for public health officials, providing an evidence-based framework to design and implement more effective policies for controlling tonsillitis.

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Publication Details

Journal
Scientific Reports
Published
2025-07-30
DOI
https://doi.org/10.1038/s41598-025-13287-7
Primary Topic
Autoimmune and Inflammatory Disorders Research
Type
article
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article

Optimal intervention design for tonsillitis transmission via compartmental modeling with stability analysis and control strategies

Shewafera Wondimagegnhu Teklu, Aydin Sezgin, Mehmet Gümüş
Scientific Reports
Autoimmune and Inflammatory Disorders Research
article

Optimal intervention design for tonsillitis transmission via compartmental modeling with stability analysis and control strategies

Shewafera Wondimagegnhu Teklu, Aydin Sezgin, Mehmet Gümüş
article en

Abstract

Tonsillitis represents a significant public health concern, particularly for children and adolescents, leading to substantial socioeconomic costs. To address this, we developed a compartmental mathematical model to investigate the disease's transmission dynamics and determine optimal intervention strategies. The model's analysis establishes the conditions for disease persistence and eradication. Using optimal control theory, we assessed the effectiveness of preventative measures as well as treatments for both acute and chronic stages of the infection. Our findings demonstrate that a multi-faceted approach is superior to any single strategy. The most effective and robust reduction in disease prevalence is achieved by an integrated strategy that combines prevention with enhanced treatment protocols. This study offers a quantitative tool for public health officials, providing an evidence-based framework to design and implement more effective policies for controlling tonsillitis.

Scientific ReportsVol. 15(1)
Debre Berhan University (ET), Zonguldak Bülent Ecevit University (TR)
Climate action
Openalex Percentile: Top 77%
Autoimmune and Inflammatory Disorders Research
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Optimal intervention design for tonsillitis transmission via compartmental modeling with stability analysis and control strategies — Shewafera Wondimagegnhu Teklu, Aydin Sezgin, et al. · Scientific Reports (2025) | TGRS Research Map | TGRS