Clinical Effect of Platelet-Rich Plasma Collaborative Care Intervention on Early-Term Knee OA

目的：通过深入研究PRP协同护理干预的机制和效果，可以为未来的骨性关节炎治疗提供更多有益的启示和指导。方法：选择2022年3月至2023年2月于我院就诊的61例膝关节骨性关节炎患者，根据护理方法的不同分成2组，对照组30例，观察组31例，其中男15例，女16例，年龄(48.09 ± 19.22)岁。对照组采用PRP协同常规护理，观察组采用PRP协同护理干预措施。记录患者的基本资料及既往史，比较治疗前后的视觉模拟评分法(VAS)、健康调查简表(SF-36)、纽卡斯尔护理满意度量表(NSNS)、美国特种外科医院膝关节功能(HSS)、Lysholm等评分，比较两组患者治疗效果。结果：① 基本资料：两组患者年龄、性别、身体质量指数、患肢、既往史(高血压、糖尿病、冠心病及内分泌系统疾病)，吸烟史及饮酒史等指标均无统计学差异(P > 0.05)；② 治疗后主要指标：两组患者VAS、SF-36、NSNS、HSS评分治疗前均无统计学差异(P > 0.05)，两组患者VAS、SF-36、NSNS评分治疗后1月、6月及12月随访时差异有统计学意义(P 0.05)，两组患者治疗后Lysholm评分有统计学差异(P Objective: Through an in-depth study of the mechanism and effects of PRP combined with nursing interventions, valuable insights and guidance can be provided for future treatment of osteoarthritis. Method: A total of 61 patients with knee osteoarthritis who visited our hospital from March 2022 to February 2023 were selected. They were divided into two groups based on different nursing methods: a control group of 30 patients and an observation group of 31 patients, including 15 males and 16 females, with an average age of (48.09 ± 19.22) years. The control group received PRP combined with routine nursing care, while the observation group received PRP combined with nursing intervention measures. Patient demographics and medical history were recorded, and treatment outcomes were compared using the Visual Analog Scale (VAS), Short Form-36 (SF-36), Newcastle Satisfaction with Nursing Scale (NSNS), Hospital for Special Surgery Knee Score (HSS), Lysholm score, and other assessments to evaluate treatment effectiveness. Results: 1) Demographics: There were no statistically significant differences (P > 0.05) between the two groups in terms of age, gender, body mass index, affected limb, medical history (hypertension, diabetes, coronary heart disease, endocrine disorders), smoking history, and alcohol consumption. 2) Main outcomes after treatment: Before treatment, there were no statistically significant differences (P > 0.05) in VAS, SF-36, NSNS, and HSS scores between the two groups. However, after 1, 6, and 12 months of follow-up, there were statistically significant differences (P 0.05), but after treatment, there were significant differences (P < 0.05) in the Lysholm scores. The total effective rate in the observation group [93.50% (29/31)] was higher than that in the control group [70% (21/30)], with statistical significance (P < 0.05). Conclusion: PRP combined with nursing interventions can effectively alleviate clinical symptoms of pain, reduced mobility, and aggravated knee osteoarthritis in early to mid-stage KOA patients, demonstrating good clinical outcomes and a certain level of effectiveness and safety in bone tissue repair. Patients’ quality of life and satisfaction have also improved.