The Value and Research Progress of Telomerase Reverse Transcriptase Gene Mutations in the Diagnosis and Treatment of Gliomas

胶质瘤(Glioma)作为最常见且侵袭性强的原发性脑肿瘤，因其发病机制复杂，治疗极具挑战，严重威胁人类健康。端粒酶逆转录酶(telomerase reverse transcriptase, TERT)在维持端粒长度中起关键作用，与胶质瘤肿瘤细胞的无限增殖密切相关。近年来，随着TERT在胶质瘤的发生、发展、影像诊断、预后评估及治疗等方面的研究不断深入，为胶质瘤的精准诊疗提供了新的方向和思路。本文就TERT基因突变与胶质瘤的关系，以及调控TERT基因突变在胶质瘤诊疗中的价值及研究进展进行综述。Glioma, as the most common and highly invasive primary brain tumor, poses a significant threat to human health due to its complex pathogenesis and the considerable challenges it presents for treatment. Telomerase reverse transcriptase (TERT) plays a critical role in maintaining telomere length and is closely associated with the unlimited proliferation of tumor cells. In recent years, with the continuous deepening of research on TERT in glioma occurrence, progression, imaging diagnosis, prognosis assessment, and treatment, new directions and insights have been provided for the precise diagnosis and treatment of glioma. This review focuses on the relationship between TERT gene mutations and glioma, as well as the value and research progress of regulating TERT gene mutations in the diagnosis and treatment of glioma.