Exploring the effects of <italic>Shiwei Qingwen Decoction</italic>(十味清瘟汤) on the immune function of immunosuppressed mice

<sec> <title>目的</title> 通过使用环磷酰胺所致免疫抑制小鼠模型,探讨十味清瘟汤(SWQWD)对免疫缺陷小鼠的免疫调节作用。 </sec> <sec> <title>方法</title> 采用环磷酰胺建造免疫抑制小鼠模型,计算脏器指数评价免疫器官功能,吞噬试验评估腹腔,MTT法检测T淋巴细胞增殖能力,LDH法检测NK细胞杀伤活性,ELISA试剂盒检测小鼠血清中相关细胞因子水平,RT-PCR检测脾脏中相关细胞因子的mRNA水平。 </sec> <sec> <title>结果</title> 与空白组比较,环磷酰胺显著抑制小鼠脾脏、胸腺指数,腹腔巨噬细胞吞噬功能、T淋巴细胞增殖能力、NK细胞杀伤活性以及免疫相关细胞因子水平;与模型组相比,SWQWD显著提高小鼠免疫器官指数,免疫细胞功能和细胞因子水平。 </sec> <sec> <title>结论</title> 十味清瘟汤能对抗环磷酰胺所导致的免疫抑制,增强了动物免疫功能。 </sec>

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Publication Details

Journal
Lishizhen medicine and materia medica research
Published
2025-05-01
DOI
https://doi.org/10.70976/j.1008-0805.szgygy-2025-0910
Primary Topic
Pharmacological Effects of Natural Compounds
Type
article
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article

Exploring the effects of &lt;italic&gt;Shiwei Qingwen Decoction&lt;/italic&gt;(十味清瘟汤) on the immune function of immunosuppressed mice

Y. Liu, Cheng‐Xiong Yang, Ping Peng, Wen Li et al.
Lishizhen medicine and materia medica research
Pharmacological Effects of Natural Compounds
article

Exploring the effects of &lt;italic&gt;Shiwei Qingwen Decoction&lt;/italic&gt;(十味清瘟汤) on the immune function of immunosuppressed mice

Y. Liu, Cheng‐Xiong Yang, Ping Peng, Wen Li, Zhen Zhou, Qing Yang, Xiao Hu
article en

Abstract

<sec> <title>目的</title> 通过使用环磷酰胺所致免疫抑制小鼠模型,探讨十味清瘟汤(SWQWD)对免疫缺陷小鼠的免疫调节作用。 </sec> <sec> <title>方法</title> 采用环磷酰胺建造免疫抑制小鼠模型,计算脏器指数评价免疫器官功能,吞噬试验评估腹腔,MTT法检测T淋巴细胞增殖能力,LDH法检测NK细胞杀伤活性,ELISA试剂盒检测小鼠血清中相关细胞因子水平,RT-PCR检测脾脏中相关细胞因子的mRNA水平。 </sec> <sec> <title>结果</title> 与空白组比较,环磷酰胺显著抑制小鼠脾脏、胸腺指数,腹腔巨噬细胞吞噬功能、T淋巴细胞增殖能力、NK细胞杀伤活性以及免疫相关细胞因子水平;与模型组相比,SWQWD显著提高小鼠免疫器官指数,免疫细胞功能和细胞因子水平。 </sec> <sec> <title>结论</title> 十味清瘟汤能对抗环磷酰胺所导致的免疫抑制,增强了动物免疫功能。 </sec>

Lishizhen medicine and materia medica researchVol. 36(9)
Zero hunger
Openalex Percentile: Top 75%
Pharmacological Effects of Natural Compounds
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