Coronary Atherosclerosis and Subclinical Cerebral Small Vessel Disease: A Robust Association Beyond Intracranial Atherosclerosis and Cardiac Systolic Function
This community-based study demonstrates an association between advanced coronary atherosclerosis and CSVD that persists after accounting for intracranial atherosclerosis and cardiac systolic dysfunction. Mendelian randomization analyses provide preliminary evidence suggesting that chronic inflammation may contribute to this association. Longitudinal studies incorporating circulating inflammatory markers are warranted to clarify these associations.
Authors
- Tiemin Wei (ORCID: https://orcid.org/0000-0002-5802-190X)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-4534-1082)
- Yuesong Pan (ORCID: https://orcid.org/0000-0003-3082-6789)
- Shan Li
- Yongjun Wang (ORCID: https://orcid.org/0000-0002-9976-2341)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Zan Wang (ORCID: https://orcid.org/0000-0003-4770-2803)
- Xueli Cai (ORCID: https://orcid.org/0000-0003-1670-3539)
Institutions
- Capital University (US)
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Institute of Neurological Disorders and Stroke (US)
- Lishui Central Hospital (CN)
- Chinese Institute for Brain Research (CN)
- Beijing Advanced Sciences and Innovation Center (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1161/jaha.125.042081
- Citations
- 3
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.56