Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model
This study establishes a quantitative framework for evaluating TB treatments in a preclinical high-burden BALB/c mouse model. The dual-metric classification framework provides sex-inclusive, quantitative performance criteria that enhance the translational relevance of preclinical efficacy studies. This approach sets relative benchmarks that support the comparative evaluation of novel regimens and helps to align preclinical performance with clinical expectations.
Authors
- Gregory T. Robertson (ORCID: https://orcid.org/0000-0001-7157-4034)
- Lisa K. Woolhiser
- Richard A. Slayden (ORCID: https://orcid.org/0000-0001-6857-7277)
- Jason E. Cummings (ORCID: https://orcid.org/0000-0001-6137-9163)
- M. Nurul Islam (ORCID: https://orcid.org/0000-0002-2396-6444)
- Barbara Graham (ORCID: https://orcid.org/0000-0002-4221-1979)
Institutions
- South Dakota State University (US)
- Colorado State University (US)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1186/s12866-025-04196-w
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Colorado State University
- National Institutes of Health