Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis

Major Finding: A Ly6GhighLy6Clow subset of neutrophils drives pleomorphic necrosis by forming intravascular neutrophil extracellular traps (NET).Concept: Tumor cells adjacent to neutrophil-induced necrotic regions undergo an epithelial-to-mesenchymal transition.Impact: Genetic or pharmacologic blockade of NET formation reduces pleomorphic necrosis and metastasis.

Publication Details

Journal: Cancer Discovery
Published: 2025-01-01
DOI: https://doi.org/10.1158/2159-8290.cd-rw2025-072
Primary Topic: Nanoplatforms for cancer theranostics
Type: article
Field-Weighted Citation Impact: 0.00

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article

Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis

Jan 1, 2025

Cancer Discovery

Nanoplatforms for cancer theranostics

article

Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis

January 1, 2025article en

Abstract

Cancer Discovery

Zero hunger

Openalex Percentile: Top 83%

Nanoplatforms for cancer theranostics

DOI Source OpenAlex

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Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis · Cancer Discovery (2025) | TGRS Research Map | TGRS