Comparison of microbial culture, metagenomic next-generation sequencing and droplet digital polymerase chain reaction methods for pathogen detection in patients with neurosurgical central nervous system infection
mNGS and ddPCR hold the potential to substantially augment the diagnostic efficacy for NCNSIs patients. It is advisable that, in future clinical practice, mNGS and ddPCR be more extensively employed for the early and precise identification of pathogens in NCNSIs patients.
Authors
- Han Gao (ORCID: https://orcid.org/0000-0002-3990-3624)
- Simei Sun
- Shili Liu (ORCID: https://orcid.org/0000-0002-3929-649X)
- Haibo Yu (ORCID: https://orcid.org/0000-0003-1506-2346)
- Qibing Huang
- Ze-Li Zhang (ORCID: https://orcid.org/0000-0003-2399-0038)
- Yan Song (ORCID: https://orcid.org/0000-0002-5847-0254)
- Xiangqian Ding
- Dong Liang (ORCID: https://orcid.org/0000-0003-1358-9777)
- Guanhua Fan (ORCID: https://orcid.org/0000-0002-7940-3501)
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fcimb.2025.1606283
- Citations
- 1
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province