Identification and validation of ubiquitination-related genes for predicting cervical cancer outcome
Our study identified five ubiquitination-related biomarkers, namely, MMP1, RNF2, TFRC, SPP1, and CXCL8, which were significantly associated with CC. The validated risk model demonstrates strong predictive value for patient survival. These findings provide crucial insights into the role of ubiquitination in CC pathogenesis and offer valuable targets for advancing future research and therapeutic strategies.
Authors
- Xiaoliang Liang (ORCID: https://orcid.org/0000-0001-6674-9354)
- Jin Ge (ORCID: https://orcid.org/0000-0001-8952-8191)
- Jun Wang (ORCID: https://orcid.org/0000-0003-2569-1461)
- Xiaomei Fan
- Honghong Dai (ORCID: https://orcid.org/0009-0005-5599-1512)
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fgene.2025.1578075
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00