Molecular subtypes, prognostic factors, and treatment optimization in pediatric medulloblastoma: a real-world study from China
This study identified key clinical and molecular risk factors associated with recurrence and mortality in pediatric medulloblastoma. The findings underscore the prognostic relevance of TP53 mutations, MYCN amplification, and specific chromosomal alterations, particularly in non-metastatic subgroups. These insights may help guide risk-adapted and personalized treatment strategies in future studies.
Authors
- Jin Zhang (ORCID: https://orcid.org/0000-0002-3806-0338)
- Yanling Sun (ORCID: https://orcid.org/0000-0002-3175-3625)
- Wanshui Wu
- Huming Li
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-7825-2679)
- Jingjing Liu (ORCID: https://orcid.org/0000-0002-5331-7015)
- Liming Sun
- Shuxu Du (ORCID: https://orcid.org/0000-0002-2874-5712)
Institutions
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- 307th Hospital of Chinese People’s Liberation Army (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fonc.2025.1597123
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University