Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers
This study elucidates the HSP90AA1-HSPA1B-DNAJB1 network as a key driver of VaD pathogenesis through dual mechanisms of protein homeostasis and immune reprogramming. The diagnostic performance of this network significantly surpasses traditional biomarkers (ΔAUC≥14.3%), offering novel targets for precision diagnostics and therapeutics. However, further validation with larger cohorts is necessary to assess its clinical translational potential.
Authors
- Chuanhong Li
- Luomeng Chao
- Mingyang Jiang (ORCID: https://orcid.org/0000-0002-1127-4838)
- Dong Wang (ORCID: https://orcid.org/0000-0003-4278-2728)
- Wentong Li (ORCID: https://orcid.org/0000-0002-8855-2162)
- Yiyi Zhang
- Yuxia Yang (ORCID: https://orcid.org/0000-0002-3118-6659)
Institutions
- Inner Mongolia University for Nationalities (CN)
- Tongliao Academy of Agricultural Sciences (CN)
- Inner Mongolia Comprehensive Disease Prevention and Control Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1615540
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84