Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs
These findings highlight the potential of guanine-based scaffolds, particularly 8-azaguanine and 7-deazaguanine, as promising leads for purine-based antimalarial drug development and the versatility of the <i>Pf</i>ENT1 transporter in the uptake of purine antimetabolites.
Authors
- Harry P. de Koning (ORCID: https://orcid.org/0000-0002-9963-1827)
- Nancy Odurowah Duah-Quashie (ORCID: https://orcid.org/0000-0001-8819-1793)
- Neils B. Quashie (ORCID: https://orcid.org/0000-0002-2538-0324)
- Worlanyo Tashie
Institutions
- University of Ghana (GH)
- Noguchi Memorial Institute for Medical Research (GH)
- University of Glasgow (GB)
Publication Details
- Journal
- Frontiers in Parasitology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fpara.2025.1634209
- Citations
- 3
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- World Bank Group
- University of Glasgow
- Noguchi Memorial Institute for Medical Research, University of Ghana