Synthetic niclosamide-loaded controlled-release nanospheres with high solubility and stability exerting multiple effects against Clostridioides difficile
These findings presented the therapeutic potential of NIC@PLGA-HAs with high solubility and stability, which simultaneously exerted multiple biological activities against <i>C. difficile</i>.
Authors
- Yulei Tai (ORCID: https://orcid.org/0000-0003-2274-9832)
- Shan Lin (ORCID: https://orcid.org/0000-0001-8717-3681)
- Xiaojun Song (ORCID: https://orcid.org/0000-0002-7971-9696)
- Shuangshuang Wan (ORCID: https://orcid.org/0009-0005-7619-3325)
- Dazhi Jin (ORCID: https://orcid.org/0000-0002-2613-7844)
- F. Y. Zhai (ORCID: https://orcid.org/0000-0001-7806-4520)
- Yu Chen (ORCID: https://orcid.org/0000-0001-7349-0686)
- Meng Zhang (ORCID: https://orcid.org/0000-0002-1300-935X)
- Menglun Tian
- Yuning Han (ORCID: https://orcid.org/0000-0002-5982-0818)
- Hui Hu (ORCID: https://orcid.org/0000-0002-3440-5415)
Institutions
- Blood Center of Zhejiang Province (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fmicb.2025.1617631
- Citations
- 1
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province