The clinical value of screening for acetaminophen in all patients with intentional overdose or altered mental status suspected to be secondary to overdose
Our study revealed that a small number of patients who presented with intentional overdose but denied APAP ingestion or AMS suspected to be due to overdose had a positive APAP level. But, Given the serious consequences of APAP toxicity we cannot recommend stopping the screening for APAP specially in high-risk suicidal patients. A larger multicenter study is recommended to identify those high-risk patients. We also found deviation from the current guidelines regarding NAC administration in patients with positive APAP level when the time of ingestion is unknown.
Authors
- Shadi Tamur (ORCID: https://orcid.org/0009-0002-8294-6707)
- Abdulaziz Alalshaikh (ORCID: https://orcid.org/0000-0003-3730-5337)
- Mosaed Alnowiser
- Zohair Al Aseri (ORCID: https://orcid.org/0000-0001-9869-7544)
- Mohammed Al Deeb
- Mohammed Almohawes
- Bader Alyahya (ORCID: https://orcid.org/0000-0002-4869-4852)
- Musa Alfaifi (ORCID: https://orcid.org/0000-0002-2535-5970)
- Rand Alrefaei
- Omar Abdullatif Alsuliman (ORCID: https://orcid.org/0009-0001-9398-1834)
- M al-Nahdi
- Sarah Alaidarous
Institutions
- Taif University (SA)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Saud University (SA)
- Armed Forces Hospital (SA)
- Ministry of Health (SA)
- Dar Al Uloom University (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fphar.2025.1633548
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University