Association between neurodevelopmental disorders in congenital heart disease and changes in circulatory metabolites and gut microbiota composition
This multi-omics study reveals significant association between altered serum metabolites, gut microbiota dysbiosis, and neurodevelopmental outcomes in children with CHD. The microbes and metabolites identified here may contribute to addressing the challenge of ND in the CHD population. Based on our findings, therapeutic strategies to reduce the risk of ND could be developed, including targeted manipulation of the gut microbiota and metabolites.
Authors
- Di Yu (ORCID: https://orcid.org/0000-0003-0801-1225)
- Siyu Ma (ORCID: https://orcid.org/0000-0001-9497-9317)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-1090-2174)
- Zhaocong Yang (ORCID: https://orcid.org/0000-0002-2133-2333)
- Xuming Mo
- Jia An
- Zihao Bai (ORCID: https://orcid.org/0000-0001-9434-4338)
Institutions
- Nanjing Children's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fmicb.2025.1639057
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China