Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study
In our cohort of critically ill children on ECMO, augmented CL and Vd were associated with low levosimendan concentrations. This suggests that dosage should be increased in this context, to achieve optimal exposure of levosimendan and its active metabolite.
Authors
- Laurent Arthur Decosterd (ORCID: https://orcid.org/0000-0002-9840-1325)
- Ermindo R. Di Paolo (ORCID: https://orcid.org/0000-0003-3843-4528)
- David Haefliger (ORCID: https://orcid.org/0000-0001-7896-0894)
- Sophie Bertin (ORCID: https://orcid.org/0000-0002-0074-9607)
- Françoise Livio (ORCID: https://orcid.org/0000-0001-7427-5953)
- Monia Guidi (ORCID: https://orcid.org/0000-0002-6419-9317)
- Marie‐Hélène Perez (ORCID: https://orcid.org/0000-0001-6173-3396)
- Thierry Buclin (ORCID: https://orcid.org/0000-0003-0639-5536)
- Vivianne Chanez
Institutions
- University of Lausanne (CH)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fped.2025.1542417
- Citations
- 1
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.67