Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injury
Murine models partially replicate human SLI pathology but exhibit distinct mechanistic emphases. Careful model selection is essential for biomarker discovery (e.g., SOCS3) and pathogenic mechanism exploration, highlighting inherent model limitations.
Authors
- Qin Yan (ORCID: https://orcid.org/0000-0002-3974-0298)
- Xiaolin Zhong (ORCID: https://orcid.org/0000-0001-5819-4272)
- Zheng Shi (ORCID: https://orcid.org/0000-0002-1921-1145)
- Xinsen He
- Wei Fan
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1556392
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China