Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet
ABCA1 exhibits marked tissue specificity under HCD feeding or CYP27A1 KO conditions. In the liver, ABCA1 downregulation may exacerbate cholesterol metabolic imbalance, while its upregulation in the lung may play an important role in maintaining cholesterol homeostasis. Moreover, the increase in pulmonary ABCA1 expression in CYP27A1 KO mice may be associated with activation of the NF-κB signaling pathway.
Authors
- Yongjia Li (ORCID: https://orcid.org/0009-0007-3563-6921)
- Xuemei Lian (ORCID: https://orcid.org/0000-0003-3625-6545)
- Hongya Liu (ORCID: https://orcid.org/0009-0003-8539-2516)
- Jian Ma (ORCID: https://orcid.org/0000-0003-3735-370X)
- Hong Lü (ORCID: https://orcid.org/0000-0003-4389-7252)
- Yuemei Zhang (ORCID: https://orcid.org/0000-0003-3555-4524)
- Qian Zhu (ORCID: https://orcid.org/0000-0003-3808-4062)
- Zhongwen Gong
- Han Yang
- Shengquan Wang
Institutions
- Dalian Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Panzhihua Central Hospital (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fnut.2025.1649407
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University