Fasting-mimicking diet enhances EGFR-TKI efficacy in oral cancer through dual mechanisms: direct cancer cell sensitization and tumor-associated macrophage crosstalk
In this study, we confirmed that fasting-mimicking diets not only directly enhances the sensitivity of oral cancer cells to gefitinib but also indirectly improves efficacy by attenuating CCL2-mediated TAMs recruitment under the gefitinib treatment environment. This study may provide a drug combination strategy and theoretical basis for the treatment of oral cancer, as well as scientific evidence for the clinical application of fasting-mimicking diets.
Authors
- Yating Yu
- Fu‐Lian Gong
- Rong Wang (ORCID: https://orcid.org/0000-0001-6553-8416)
- Lei Wang (ORCID: https://orcid.org/0000-0003-4341-5305)
- Yongfang Yuan (ORCID: https://orcid.org/0000-0003-4093-8725)
- Jiyuan Chen (ORCID: https://orcid.org/0000-0002-8516-720X)
- Zhiquan Qiu (ORCID: https://orcid.org/0009-0003-8383-2776)
- Yujie Wang (ORCID: https://orcid.org/0009-0009-6010-2571)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fphar.2025.1641024
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China