Mechanism of action of decitabine in treating acute lymphoblastic leukemia
By selectively targeting the regulation of PTEN and 4EBP1, along with their associated downstream signaling pathways, DAC effectively modulated cellular proliferation, facilitated apoptotic processes, and restrained tumor growth, providing a robust theoretical foundation for clinical treatment strategies in T-ALL.
Authors
- Xiaoyan Zhao (ORCID: https://orcid.org/0000-0001-8474-7416)
- Xiaohui Gao (ORCID: https://orcid.org/0000-0001-7051-702X)
- Yuan Li (ORCID: https://orcid.org/0000-0002-7233-2720)
- Minchao Yan
- Haibing Wu
- Qinglin Fu (ORCID: https://orcid.org/0000-0002-2349-4635)
- Fei Sun (ORCID: https://orcid.org/0000-0002-0870-8375)
- Gang Zhang (ORCID: https://orcid.org/0000-0002-5337-3164)
- Hui Zeng (ORCID: https://orcid.org/0000-0002-2076-7458)
Institutions
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fmed.2025.1614592
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical and Health Research Project of Zhejiang Province