Osteogenic shift in the adipose-derived stem cells of Acomys cahirinus is linked to impaired adipose tissue self-renewal
We conclude that <i>Acomys cahirinus</i> ADSC have high regenerative potential. Nevertheless, the augmented osteogenic capacity of <i>Acomys cahirinus</i> ADSC can be related with a limited ADSC participation in adipose tissue self-renewal. The reduction in ATGL expression observed in <i>Acomys cahirinus</i> adipose tissue may serve as a protective mechanism in the face of excessive adipose tissue accumulation.
Authors
- Ekaterina Zubkova (ORCID: https://orcid.org/0000-0002-0512-3670)
- Margarita Agareva (ORCID: https://orcid.org/0000-0002-9603-9780)
- Y E Parfyonova
- И. Б. Белоглазова (ORCID: https://orcid.org/0000-0002-2345-3681)
- Natalia Alekseeva (ORCID: https://orcid.org/0000-0001-7681-2900)
- Е. И. Ратнер (ORCID: https://orcid.org/0000-0003-0920-4029)
- M. A Boldyreva (ORCID: https://orcid.org/0000-0002-8309-0018)
- Iurii Stafeev (ORCID: https://orcid.org/0000-0003-3514-3936)
- Svetlana Michurina (ORCID: https://orcid.org/0000-0001-6027-2217)
- E. Trubkina
Institutions
- National Research University Higher School of Economics (RU)
- Lomonosov Moscow State University (RU)
- Institute of Experimental Cardiology (RU)
- National Medical Research Center of Cardiology (RU)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fcell.2025.1603405
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation