Association of TCRαβ+ double-negative T cells with the response to glucocorticoids in pediatric patients with immune thrombocytopenia
TCRαβ<sup>+</sup>DNT appears to play a significant role in the pathogenesis of pediatric ITP and may be involved in the immune response to HD-DXM. The correction of elevated TCRαβ<sup>+</sup>DNT in patients who respond to HD-DXM may provide a novel insight for immune therapy in pediatric ITP.
Authors
- Runhui Wu (ORCID: https://orcid.org/0000-0003-4030-209X)
- Hui Chen (ORCID: https://orcid.org/0000-0002-0048-0193)
- Zhenping Chen (ORCID: https://orcid.org/0000-0002-5273-145X)
- Lingling Fu (ORCID: https://orcid.org/0000-0002-5611-9188)
- Xingjuan Xie (ORCID: https://orcid.org/0000-0002-3789-9182)
- Jingyao Ma (ORCID: https://orcid.org/0000-0003-3737-0876)
Institutions
- National Clinical Research (US)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1645932
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Beijing Municipal Health Commission
- National Institutes of Natural Sciences