Case Report: Treatment of delayed tremor episodes in a patient with DPPX antibody encephalitis

The current patient is the first reported case of Anti-DPPX encephalitis presenting with delayed tremor accompanied by blurred vision. The patient's condition was quite fluctuating, which led us to discuss the diversity of symptoms as related to extrapyramidal and occipital lobe damage caused by immune-mediated inflammation. Symptom improvement was achieved through a combination of IVMP, eculizumab, and ofatumumab treatments. The prodromal symptoms of Anti-DPPX encephalitis are easily misdiagnosed as infectious diseases due to the heterogeneity of its clinical manifestations. Early identification of the antibody and initiation of immunotherapy can improve the prognosis.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-07-30
DOI
https://doi.org/10.3389/fimmu.2025.1594823
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
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article

Case Report: Treatment of delayed tremor episodes in a patient with DPPX antibody encephalitis

Miao Yu, Jenny Yan, X. Liu
Frontiers in Immunology
Autoimmune Neurological Disorders and Treatments
article

Case Report: Treatment of delayed tremor episodes in a patient with DPPX antibody encephalitis

Miao Yu, Jenny Yan, X. Liu
article en

Abstract

The current patient is the first reported case of Anti-DPPX encephalitis presenting with delayed tremor accompanied by blurred vision. The patient's condition was quite fluctuating, which led us to discuss the diversity of symptoms as related to extrapyramidal and occipital lobe damage caused by immune-mediated inflammation. Symptom improvement was achieved through a combination of IVMP, eculizumab, and ofatumumab treatments. The prodromal symptoms of Anti-DPPX encephalitis are easily misdiagnosed as infectious diseases due to the heterogeneity of its clinical manifestations. Early identification of the antibody and initiation of immunotherapy can improve the prognosis.

Frontiers in ImmunologyVol. 16
First Affiliated Hospital of Henan University of Science and Technology (CN)
Good health and well-being
Openalex Percentile: Top 72%
Autoimmune Neurological Disorders and Treatments
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