ENHANCING THE SOLUBILITY OF RITONAVIR SOLID DISPERSION USING SPRAY DRYING TECHNIQUE

The Proposed investigation was focus on Improvement in the solubility of Ritonavir (BCS-II, anti-HIV drug).Addition of soluplus as polymer which is compatible with active ingredient to increase its solubility will be the main objective of research work.The solid dispersion was prepared by the spray drying technique using Drug and polymer in 1:3 ratios.The prepared solid dispersions of Ritonavir were characterized by XRD, DSC thermogram, % Entrapment Efficiency.In the present research work, a spray drying technique was successfully developed for the preparation of Solid Dispersion of ritonavir exhibiting improved solubility thereby increase rate of dissolution and oral bioavailability.The final batch of solid dispersion of Ritonavir with Soluplus shows the higher solubility in 0.1 N HCL, pH 7.2 buffer compare with pH 6.8 buffer and pH 5.4 buffer.The developed technique could be successfully applied for solubility enhancement of other BCS-II drugs also.