Energy Metabolism: Involvement and Role in the Pathogenesis and Progression of Systemic Sclerosis

系统性硬化症(Systemic Sclerosis, SSc)是以皮肤和内脏纤维化为特征的自身免疫性疾病，其发病机制与能量代谢密切相关。近些年的研究表明，SSc患者真皮成纤维细胞呈现代谢异常，包括糖酵解增强、脂质代谢紊乱、谷氨酰胺依赖性代谢激活以及线粒体氧化磷酸化失调。本文综述能量代谢在SSc发生发展中的参与和重要性，为揭示SSc发病机制和开发新型治疗药物提供参考。 Systemic Sclerosis (SSc) is an autoimmune disease characterized by skin and visceral fibrosis, and its pathogenesis is closely related to energy metabolism. Recent studies have shown that dermal fibroblasts in SSc patients exhibit metabolic abnormalities, including enhanced glycolysis, disordered lipid metabolism, activation of glutamine-dependent metabolism, and dysregulation of mitochondrial oxidative phosphorylation. This article aims to review the involvement and significance of energy metabolism in the onset and development of systemic sclerosis, providing a theoretical basis for a deeper understanding of the pathogenesis of SSc and the development of novel therapeutic drugs.