Combined Effect of Triglyceride-Glucose Index and Atherogenic Index of Plasma on Cardiovascular Disease

目的：探讨甘油三酯–葡萄糖指数(triglyceride-glucose index, TyG)与血浆致动脉硬化指数(atherogenic index of plasma, AIP)对新发心血管疾病(cardiovascular disease, CVD)的综合影响。方法：应用前瞻性队列研究，选取参加2006年度体检的开滦研究人群(n = 96,391)作为研究对象，将参与者按TyG和AIP中位数进行分组，分为低TyG &低AIP组，低TyG &高AIP组，高TyG &低AIP组，高TyG &高AIP组，每两年进行一次随访，以发生CVD (包括缺血性心脏病、卒中)、死亡或随访结束(2022年12月31日)为随访终点，分析TyG联合AIP与CVD发生风险的关联。结果：96,391名观察对象在平均随访14.17 ± 3.81年后，发生CVD者共11,378名。校正混杂因素后，与低TyG &低AIP组相比，高TyG &高AIP组发生CVD的HR (95%CI)为1.213 (1.156~1.272)，Ptrend Objective: To investigate the combined effects of the triglyceride glucose index (TyG) and atherogenic index of plasma (AIP) on new-onset cardiovascular disease (CVD). Methods: This prospective cohort study used data from the Kailuan study population (n = 96,391), which included participants who underwent a physical examination in 2006. Based on median TyG and AIP values, participants were categorized into four groups: low TyG & low AIP, low TyG & high AIP, high TyG & low AIP, and high TyG & high AIP. Follow-up was conducted every two years. The study endpoints included incident CVD (ischemic heart disease or stroke), death, or the end of follow-up (December 31, 2022). The association between TyG combined with AIP and CVD risk was then analyzed. Results: After a mean follow-up period of 14.17 ± 3.81 years, 11,378 participants developed CVD. After multivariable adjustment, compared with the low TyG and low AIP group, the high TyG and high AIP group showed significantly increased CVD risk (HR = 1.213, 95%CI: 1.156~1.272); P for trend <0.05. Conclusion: High TyG combined with high AIP can promote the occurrence of CVD.