UHMK1 Promotes Prostate Cancer Progression through a Positive Feedback Loop with MTHFD2
In conclusion, our data suggest that the UHMK1-MTHFD2 axis forms a positive feedback loop that drives PCa progression. Targeting this loop represents a promising therapeutic strategy for restraining prostate cancer development and progression.
Authors
- Zhuolun Sun
- Xiangfu Zhou (ORCID: https://orcid.org/0000-0002-7223-6691)
- Jianjie Wu (ORCID: https://orcid.org/0000-0002-7585-5201)
- Cheng Hu (ORCID: https://orcid.org/0000-0001-8666-8471)
- Bowen Tang (ORCID: https://orcid.org/0000-0003-4072-4903)
- Xi Huang (ORCID: https://orcid.org/0000-0002-0896-6980)
- Hengjun Xiao (ORCID: https://orcid.org/0000-0001-5472-2154)
- Weian Zhu (ORCID: https://orcid.org/0000-0002-5765-3593)
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-8180-2384)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.065119
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81