Inhibition of Proteasome LMP2 Activity Suppresses <i>Chil3</i> Expression in Mouse Colon Adenocarcinoma Tissue and Restrains Tumor Growth
We discovered earlier unknown functions of the proteasome LMP2 subunit to facilitate the formation of tumor conglomerates and maintain <i>Chil3</i> and <i>Arg1</i> expression in immunosuppressive M2 macrophages. Our work demonstrates that the proteasome LMP2 subunit can be a target for antitumor treatment.
Authors
- Nataliya O. Dashenkova (ORCID: https://orcid.org/0000-0002-9288-7096)
- A. S. Ryabchenko (ORCID: https://orcid.org/0000-0001-5200-1273)
- P. A. Erokhov
- Nikita S Karpov
- Н. П. Шарова (ORCID: https://orcid.org/0000-0002-6976-2105)
- Arsen Mikaelyan (ORCID: https://orcid.org/0000-0003-4358-2357)
- Mikhail V. Nesterchuk (ORCID: https://orcid.org/0000-0002-0856-8851)
- Е. В. Алпеева (ORCID: https://orcid.org/0000-0003-2757-9991)
- Т. М. Астахова
- Sergey B. Akopov
Institutions
- Koltzov Institute of Developmental Biology (RU)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.066611
- Citations
- 2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.61