Study on the Multi-Mechanism of Cardiac Arrest and Microcirculation Disorder Regulated by Shenfu Injection: Clinical and Basic Progress

心脏骤停(CA)及心肺复苏(CPR)后微循环障碍是导致复苏后多器官功能障碍综合征(PR-MODS)和患者死亡的关键因素。参附注射液(SFI)作为源自经典方剂参附汤的中药注射剂，近年研究表明其在改善CPR后微循环障碍中具有显著潜力，机制涉及血流动力学调节、抗炎、抗氧化及细胞保护等多途径。本文旨在对参附注射液在心脏骤停后心肺复苏患者微循环障碍治疗中的作用进行综述，为临床使用参附注射液干预心脏骤停后心肺复苏患者微循环障碍的进程提供新的思路和参考。Cardiac arrest (CA) and microcirculatory disorders after cardiopulmonary resuscitation (CPR) are key factors leading to post-resuscitation multi-organ dysfunction syndrome (PR-MODS) and patient mortality. Shenfu Injection (SFI), a traditional Chinese medicine injection derived from the classic formula Shenfu Decoction, has shown significant potential in improving microcirculatory disorders after CPR in recent studies. The mechanisms involve multiple pathways such as hemodynamic regulation, anti-inflammatory effects, antioxidant activity, and cell protection. This article aims to review the role of Shenfu Injection in treating microcirculatory disorders in patients who have undergone cardiopulmonary resuscitation following cardiac arrest, providing new insights and references for its clinical use in managing microcirculatory disorders in post-resuscitation patients.