Palladium-catalyzed tandem cyclization reaction: access to isoxazoline-benzofuran bis-heterocycles
A novel palladium-catalyzed carboetherification reaction of β,γ-unsaturated ketoxime with <i>gem</i>-dihaloolefin has been developed. This process offers an efficient route for the assembly of isoxazoline-linked benzofuran/indole bis-heterocycles in moderate to good yields. The scalability of the reaction and subsequent transformations of the products highlight the synthetic potential of this developed method.
Authors
- Weiming Hu (ORCID: https://orcid.org/0000-0002-0157-1089)
- Xiuzhao Yu
- Lei Wang (ORCID: https://orcid.org/0000-0002-8792-0234)
- Shuwei Zhang (ORCID: https://orcid.org/0000-0002-1879-9063)
- Qing Wu (ORCID: https://orcid.org/0009-0003-4618-1580)
- Tian Tang
- Guofeng Zhao (ORCID: https://orcid.org/0000-0001-7919-1898)
- Yingna Han
Institutions
- Henan University of Science and Technology (CN)
- Shanghai Xuhui Central Hospital (CN)
- Shanghai Ocean University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02682b
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province