A Pd nanoparticle-loaded nanoscale covalent organic framework to enhance tumor therapy by synergistic hydrogen/photothermal therapy
Herein, we report a nanoscale composite COF material loaded with Pd nanoparticles and H<sub>2</sub><i>via</i> a stepwise post-synthetic modification. The obtained PdH<sub>0.18</sub>@COF was shown to affect mitochondrial function by disrupting the intracellular redox balance and thus down-regulating the expression of heat shock proteins (HSPs), thereby enhancing the photothermal therapy of tumors.
Authors
- Yang Lü (ORCID: https://orcid.org/0000-0002-8412-809X)
- Yu‐Bin Dong (ORCID: https://orcid.org/0000-0002-9698-8863)
- Haoran Wang (ORCID: https://orcid.org/0000-0002-4622-0119)
- Mingjun Gao (ORCID: https://orcid.org/0000-0002-8948-9185)
- Kai-Xuan Zhang
- Jin-Zhou Lv
- Yanan Li (ORCID: https://orcid.org/0000-0002-7083-4022)
Institutions
- Shandong Normal University (CN)
- Ministry of Education (ME)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03085d
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00