Mild hypothermia (35°C) reduces myocardial ischemia-reperfusion injury and attenuates hypoxia induced apoptosis of H9C2 cardiomyocytes by changing the phosphorylation level of Connexin43 (Cx43) protein
Mild hypothermia can protect against myocardial ischemia-reperfusion injury by regulating the level of phosphorylated Cx43 protein, which reduces myocardial cell apoptosis and enhances cardiac function. This study highlights the potential therapeutic benefits of mild hypothermia in treating ischemia-reperfusion injury.
Authors
- Jiaxin Kou (ORCID: https://orcid.org/0000-0002-7947-8212)
- Tianxun Wang
- Dianyuan Li (ORCID: https://orcid.org/0000-0002-2823-1500)
- Fang Wang (ORCID: https://orcid.org/0000-0003-0871-3454)
- Yuanming Lu
- Zilian Fan
- Lan Xiong (ORCID: https://orcid.org/0000-0003-2760-8721)
- Nanping Xiao
Institutions
- Suzhou Municipal Hospital (CN)
- Fourth People's Hospital of Taiyuan (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- African Health Sciences
- Published
- 2025-05-09
- DOI
- https://doi.org/10.4314/ahs.v25i1.18
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University