Klotho’s Impact on Cardiovascular Disease, Fractures, and Mortality in Hemodialysis

These findings suggest that low serum sKlotho levels are strongly associated with poor cardiovascular and skeletal outcomes and increased mortality in patients on hemodialysis. This study highlights the potential utility of sKlotho as a biomarker for risk stratification in this high-risk population.

Authors

Yuriko Shibata
S. Tanimoto
Rena Kawai
Ichiro Ohkido (ORCID: https://orcid.org/0000-0003-3905-9395)
Akio Nakashima (ORCID: https://orcid.org/0000-0002-3730-0301)
Chiharu Aizawa
Kazuhiko Kato (ORCID: https://orcid.org/0000-0001-9197-9434)
Takashi Yokoo
Arisa Kobayashi

Institutions

Jikei University School of Medicine (JP)

Publication Details

Journal: Kidney International Reports
Published: 2025-07-31
DOI: https://doi.org/10.1016/j.ekir.2025.07.032
Primary Topic: Parathyroid Disorders and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Japan Society for the Promotion of Science

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article

Klotho’s Impact on Cardiovascular Disease, Fractures, and Mortality in Hemodialysis

Yuriko Shibata, S. Tanimoto, Rena Kawai, Ichiro Ohkido et al.

Jul 31, 2025

Kidney International Reports

Parathyroid Disorders and Treatments

article

Klotho’s Impact on Cardiovascular Disease, Fractures, and Mortality in Hemodialysis

Yuriko Shibata, S. Tanimoto, Rena Kawai, Ichiro Ohkido, Akio Nakashima, Chiharu Aizawa, Kazuhiko Kato, Takashi Yokoo, Arisa Kobayashi

July 31, 2025article en

Abstract

These findings suggest that low serum sKlotho levels are strongly associated with poor cardiovascular and skeletal outcomes and increased mortality in patients on hemodialysis. This study highlights the potential utility of sKlotho as a biomarker for risk stratification in this high-risk population.

Kidney International ReportsVol. 10(10)

Jikei University School of Medicine (JP)

Japan Society for the Promotion of Science

Good health and well-being

Openalex Percentile: Top 79%

Parathyroid Disorders and Treatments

DOI Open Access PDF OpenAlex

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