The Relationship of Tumor Infiltrating Lymphocytes (TIL) with The Clinicopathological Picture of Colorectal Carcinoma at Prof. Dr. I.G.N.G Ngoerah Hospital Denpasar

Background: Colorectal carcinoma is defined as a malignancy in the gastrointestinal tract originating from the colon tissue, which can be the colon and/or rectum, ranking 3rd worldwide and is the 3rd most common type of cancer in men and 2nd most common cancer in women. The innate immune system has a role in the pathogenesis of colorectal carcinoma, both in the suppression of tumor cells and the escape of tumor cells from the immune system. Tumor Infiltrating Lymphocytes (TIL) are all types of immune cells that migrate from the blood to tumor cells, which can recognize and kill tumor cells. The relationship between TIL and clinicopathologic features in colorectal carcinoma has been widely mentioned in various literature and previous studies. Objective: To determine the relationship between TIL density and clinicopathological features of colorectal carcinoma (age, gender, primary tumor site, clinical stage, histopathology type, and grade of differentiation) at Prof. Dr. I.G.N.G Ngoerah Hospital, Denpasar. Methods: This study is an analytical observational study with a cross-sectional research design. The study population was patients who had been diagnosed with colorectal carcinoma from January 2021 to January 2023, with a total of 36 samples. Data taken from the Department of Clinical Pathology and the Medical Records Department of Prof. Dr. I.G.N.G. Ngoerah Denpasar Hospital and analyzed using SPSS ver 25.0, and univariate and bivariate tests were carried out. Results: In the bivariate test using chi square, a significant relationship was found between TIL density and the histopathology type of colorectal carcinoma (p 0.002) as well as between TIL density and the degree of colorectal carcinoma differentiation (p <0.001). In the Spearman correlation test and obtained a significant correlation was negative with a p-value of 0.002, CC -496. Conclusion: There was no relationship and correlation between TIL and age, gender, primary tumor site and clinical stage in colorectal carcinoma patients, and there was a significant relationship between histopathology type and grading differentiation with TIL in colorectal carcinoma patients but histopathology type was not found to be correlated with TIL while grading differentiation had a significant correlation with TIL in colorectal carcinoma patients.