Aggressive Cervical Cancer in Young Women: Immunobiology Perspectives

Cervical cancer is one of the leading causes of cancer-related deaths in women, mainly caused by human papillomavirus (HPV). Due to HPV’s nature and latency, patients are dominated by older women. The existence of aggressive cervical cancer in young women has raised concerns. Immune dysregulation, chronic inflammation, hormonal influences, and persistent HPV infection may contribute to a tumor-promoting microenvironment. Non-squamous histological types are frequently found in younger patients. Additionally, ongoing research regarding cervical cancer stem cells (CCSCSs) may also explain the rapid tumor progression and treatment resistance in this subgroup. This review will discuss how cervical cancer could present aggressive behavior in young women through immunobiological perspectives.