Effect of Intravenous Lidocaine on Postoperative Cognitive Dysfunction in Patients Undergoing Laparoscopic Colorectal Surgery: A Two-Center, Randomized, Double-Blind Controlled Trial
Perioperative administration of intravenous lidocaine has been shown to significantly enhance cognitive function on the seventh postoperative day following laparoscopic colorectal surgery. The mediating influence of propofol on the association between lidocaine and the occurrence of POCD at this time point was determined to be 10%.
Authors
- Jing Dai (ORCID: https://orcid.org/0000-0002-9282-4052)
- Xianxue Wang (ORCID: https://orcid.org/0000-0001-7793-7991)
- Hua-jing Guo
- Yan Zhang (ORCID: https://orcid.org/0000-0001-8484-6596)
- Ke-Peng Liu
- Qi Wang (ORCID: https://orcid.org/0000-0001-6341-6087)
- Feifei Cao (ORCID: https://orcid.org/0000-0001-5427-5649)
- Furong Huang (ORCID: https://orcid.org/0000-0001-8760-439X)
- Huiwei Deng (ORCID: https://orcid.org/0009-0006-7514-4609)
- Yong Chen
- L‐R Mo
- Yun Liu
Institutions
- Central South University (CN)
- Zhongshan People's Hospital (CN)
- The First People's Hospital of Changde (CN)
Publication Details
- Journal
- Current Therapeutic Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.curtheres.2025.100808
- Primary Topic
- Cardiac, Anesthesia and Surgical Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00